Tohoku J. Exp. Med., 2003, 200 (3)

Short Report

Antiviral Activity of 2-Amino-4, 4a -Dihydro-4a -7-
Dimethyl-3H-Phenoxazine-3-One on Poliovirus

AKIKO IWATA, TERUHIDE YAMAGUCHI, KOUEI SATO,¹
RYUTARO IZUMI² and AKIO TOMODA³

Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, Tokyo 158-0098,
¹The Institute of Saitama Red Cross Center, Kumagaya 360-0806,
²Office of Space Utilization Systems, Space Utilization Research Center,
National Space Development Agency of Japan (NASDA), Tsukuba 305-8505, and
³Department of Biochemistry, Tokyo Medical University, Tokyo 160-0022

2-Amino-4, 4a-dihydro-4a-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 mg/ml and 2 mg/ml with maximal antiviral acitivity at 1 mg/ml. These results suggest that Phx may be useful to prevent the proliferation of poliovirus infection.

keywords —— 2-amino-4, 4a-dihydro-4a-7-dimethyl-3H-phenoxazine-3-one; poliovirus

© 2003 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2003, 200, 161-165

Address for reprints: Akio Tomoda, Department of Biochemistry, Tokyo Medical University, Shinjuku 6-1-1, Tokyo 160-0022, Japan.

e-mail: tomoda@tokyo-med.ac.jp