Tohoku J. Exp. Med., 2003, 200 (3)

Case Report

End-Stage Kidney at the Onset of Nephrotic
Syndrome in a 4-Year-Old Girl

TOHRU NAKAHATA, HIROSHI TANAKA, KAZUSHI TSURUGA, JUN SHIMADA, KOJI TSUGAWA,
KOICHI SUZUKI, NORIO ONODERA¹ and ETSURO ITO

Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki 036-8562, and
¹Iwate Prefectural Kitakami Hospital, Kitakami 024-0063

A previously healthy Japanese girl aged 4 years suddenly developed idiopathic nephrotic syndrome (INS) associated with acute renal failure (ARF). Despite prompt initiation of hemodialysis and prednisolone treatment, her ARF did not recover. A percutaneous renal biopsy performed within a month from the onset of INS revealed lesions of end-stage kidney, which is unusual for the acute stage of INS. Although the etiology of her ARF remains speculative, an acute exacerbation of an underlying chronic disease, such as non-nephrotic focal segmental glomerulosclerosis might be the cause.

keywords —— acute renal failure; collapsing glomerulopathy; end-stage kidney; focal segmental glomerulosclerosis; idiopathic nephrotic syndrome

© 2003 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2003, 200, 151-154

Address for reprints: Hiroshi Tanaka, M.D., Department of Pediatrics, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.

e-mail: hirotana@cc.hirosaki-u.ac.jp