Tohoku J. Exp. Med., 2003, 200 (2)

Case Report

Clear Cell Myoepithelial Carcinoma of the Breast: A Case Report

YASUHIRO MIURA, AKIRA KUROSE, MAKOTO KONDO,¹ AKIRA MARUYAMA,²
YUJI SHIBATA, HIROYUKI KANNO and TAKASHI SAWAI

The First Department of Pathology, School of Medicine, Iwate Medical University Morioka 020-8505, ¹Hachinohe Heiwa Hospital, Hachinohe 031-0823, and ²Maruyama Clinic, Hachinohe 031-0823

Primary clear cell myoepithelial carcinoma (CCMC) is extremely rare. During the past twenty years, only one CCMC case has been reported. Here, a case of CCMC is reported. A 30-year-old woman became aware of an abnormal mass on the left breast, and quadrantectomy was performed. Microscopically, it consisted of tumor cells that had clear cytoplasm and showed an invasive growth pattern. Immunohistochemically, the tumor was positive for a-smooth muscle actin, S-100, partly positive for vimentin and epithelial membranous antigen. From these findings, the tumor was diagnosed as CCMC. Most of the clear cell myoepithelial tumors are probably misclassified in other examples. It is expected that the numbers of CCMC may be increased by routinely performing special stains and immunohistochemical stains, even without ultrastructual study.

keywords —— clear cell myoepithelial carcinoma; breast; immunohistochemical staining; S-100; HHF-35

© 2003 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2003, 200, 103-109

Address for reprints: Yasuhiro Miura, The First Department of Pathology, School of Medicine, Iwate Medical University, 19 Uchimaru Morioka 020-8505, Japan.

e-mail: ysmiura@iwate-med.ac.jp
Present address for Makoto Kondo, Matsuzono Clinic, 3-9-4 Matsuzono-cho, Misawa 033-0037, Japan.