Tohoku J. Exp. Med., 2003, 200 (1)

Laryngeal Cancer: in Relation to Oxidative Stress

ENDER INCI, SABIHA CIVELEK,¹ ARZU SEVEN,¹ FIGEN INCI,¹
NAZIM KORKUT and GÜLDEN BURÇAK¹

Department of Otolaryngology-Head and Neck Surgery, ¹Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Turkey

This study was designed to investigate the oxidative stress parameters in laryngeal cancer and cancer-free adjacent tissues. Lipid peroxidation end product and the endogenous antioxidant components-CuZn superoxide dismutase (CuZnSOD) glutathione peroxidase (GSH Px), glutathione reductase (GSSG Rd) and glutathione (GSH)-were analysed by spectrophotometric and kinetic methods. Laryngeal cancer tissue exhibited higher lipid peroxidation than cancer free adjacent tissue. CuZn SOD and GSH Px activities and GSH level were significantly higher and GSSG Rd activity significantly lower in the cancer tissue. Detection of the antioxidant status may be useful to determine the tumour resistance to therapy, to choose the correct radiotherapy/chemotherapy and to monitor the effectiveness of the therapetic strategy.

keywords —— lipid peroxidation; superoxide dismutase; glutathione; glutathione peroxidase/reductase; laryngeal cancer

© 2003 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2003, 200, 17-23

Address for reprints: Ender Inci, Istanbul Universitesi, Cerrahpasa Tip Fak. KBB ABD, Fatih, Istanbul, Turkey.

e-mail: ender@tkbbv.org.tr