Tohoku J. Exp. Med., 2003, 199(2)

Case Report

Pulmonary Lymphangioleiomyomatosis: A Case Report with
Immunohistochemical Details and DNA Analysis

LI-HUA PAN, HARUMASA ITO,¹ AKIRA KUROSE, KOHEI YAMAUCHI,¹
HIROSHI INOUE¹ and TAKASHI SAWAI

The First Department of Pathology, and ¹The Third Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka 020-8505

A 47-year-old woman is presented with pulmonary lymphangioleiomyomatosis (PLAM) involving the bilateral lung and slight pulmonary function abnormality. Computed tomography scan showed bilateral microcyst formation in the lung. Histologically, proliferating spindle shaped cells with centrilobular emphysema were main findings. Immunohistochemically, these proliferating spindle shaped cells were positive for a-smooth muscle actin, desmin, vimentin, HMB45, estrogen receptor and progesterone receptor, but negative for S-100, cytokeratin. Single strand conformation polymorphism (SSCP) and DNA analysis for tuberous sclerosis 1 and 2 showed no significant abnormality.

Keywords —— pulmonary lymphangioleiomyomatosis; HMB45

© 2003 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2003, 199, 119-126

Address for reprints: Takashi Sawai, M.D., Ph.D., The First Department of Pathology, Iwate Medical University School of Medicine, Uchimaru 19-1, Morioka 020-8505, Japan.

e-mail: tsawai@iwate-med.ac.jp