Tohoku J. Exp. Med., 2002, 197 (2)

Humoral GalNAca1-3GalNAc-Lipid Reactivity
of Humans in Hypomanic State

YUTAKA MASUDA, JUNYA SUGAWARA,¹ SHUN OHNUMA¹ and TOSHIHIRO SUGIYAMA²

Psychosomatic Division, ¹Department of Neuropsychiatry, ²Department of Biochemistry,
Akita University School of Medicine, Akita 010-8543

A glycolipid having GalNAca1-3GalNAc in the terminal increases a behavior climbing in a depression model, mouse forced swimming. Antidepressants, which sometimes induce hypomanic state in patients, increase the glycolipid and an anti-manic substance lithium decreases the glycolipid in mice. We detected the humoral GalNAca1-3GalNAc-lipid reactivity of humans in different affective states. Although the reactivity was also showed in serums of the depression patients and the volunteers without affective disorders, the reactivity was remarkably increased in serums of hypomania patients. These strongly suggest that the humoral glycolipid increased the activities of the hypomania patients, but did not relate to the decrease of the activities in the depression patients.

Keywords —— glycolipid; GalNAca1-3GalNAc; hypomanic state; affective disorders

© 2002 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2002, 197, 115-118

Address for reprints: Yutaka Masuda, Psychosomatic Division, Department of Neuropsychiatry, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.