Tohoku J. Exp. Med., 2002, 197(1)

Review

Molecular Biology of Blood Pressure Regulatory Genes

KAZUHISA TAKEUCHI

Division of Nephrology, Endocrinology, and Vascular Biology, Tohoku University Graduate School of Medicine, Sendai 980-8574

Blood pressure is determined by vascular resistance and circulating volume. Activation of vascular angiotensin II or thromboxane receptor is mostly involved in the former, and function of renal prostagalandin EP₃ receptor or thiazide-sensitive sodium-chloride co-transporter is also in the latter. We have cloned rat genes for these blood pressure regulatory factors, and studied their gene expression. Here we review the molecular biology of those genes, based on our observations.

Keywords —— Translational medicine; HFH-3; NRF-2; Sp-1; PPAR-g, Gitelman's syndrome.

© 2002 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2002, 197, 1-8

Address for reprints: Kazuhisa Takeuchi, M.D., Division of Nephrology, Endocrinology, and Vascular Biology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

e-mail: hek293@mail.cc.tohoku.ac.jp

Dr. K. Takeuchi is a recipient of the 2000 Gold Prize, Tohoku University School of Medicine.