Tohoku J. Exp. Med., 2002, 196 (4)

Case Report

Subsequent Progression to Membranous Glomerulonephritis Following
Exacerbation of Urticarial Rash in Systemic
Lupus Erythematosus: Report of 2 Cases

KOICHI SUZUKI, HIROSHI TANAKA, TOHRU NAKAHATA, YUKO FUKUYAMA,
ETURO ITO and SHINOBU WAGA¹

Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki
036-8562, and ¹Division of Pediatrics, National Sanatorium Iwaki
Hospital, Namioka 038-1331

Two Japanese female adolescents with systemic lupus erythematosus (SLE), known cases of urinary tract involvements: one with biopsy-proven class II lupus nephritis and the other one with lupus cystitis without overt glomerulonephritis (silent lupus), who after more than 4 years' observation presented with subsequent progression to membranous glomerulonephritis (MGN) following exacerbation of urticarial rash. Although it is well known that lupus nephritis shows histological transformation with time, the late progression to MGN from another World Health Organization histologic pattern has been reported to be less common in pediatric-onset SLE. Although pathogenesis of their MGN remains speculative, these clinical observation might suggest that a possible association between exacerbation of urticarial rash and subsequent progression to MGN in the selected patients with SLE.

Keywords—— membranous glomerulonephritis; systemic lupus erythematosus; subsequent progression; urticarial rash

© 2002 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2002, 196, 293-298

Address for reprints: Hiroshi Tanaka, M.D., Department of Pediatrics, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.

e-mail: hirotana@cc.hirosaki-u.ac.jp