Tohoku J. Exp. Med., 2001, 194 (4)

Glycoside in Schizophrenic Patients Sera Affects Behavior of
Mouse Forced Swimming

YUTAKA MASUDA, SHUN OHNUMA,¹ JUNYA SUGAWARA¹ and TOSHIHIRO SUGIYAMA²

Psychosomatic Division, ¹Department of Neuropsychiatry, and
²Department of Biochemistry, Akita University School of Medicine, Akita 010-8543

We found a glycoside in sera of schizophrenic patients. This glycoside increased climbing of mouse forced swimming and the climbing was decreased by dopamine D1 receptor antagonist SCH-23390 with a dose dependent manner. This glycoside had much reactivity of GalNAca1-3GalNAc, but not that of polymannoses nor that of Galb1-3GlcNAca1-serine or threonine. This strongly suggests that the glycoside is an isolated O-glycoside, but not N-glycoside nor O-glycoside having core 1 or 2. The present findings suggest that schizophrenic patients have the special glycoside affecting the D1 receptor activity in their serum.

Keywords —— Schizophrenic patients; glycoside; dopaminergic neuronal activities; mouse forced swimming

© 2001 Tohoku University Medical Press

===============================

Tohoku J. Exp. Med., 2001, 194, 223-228

Address for reprints: Yutaka Masuda, Psychosomatic Division, Department of Neuropsychiatry, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.