Tohoku J. Exp. Med., 2001, 194 (1)

A Protein in the Cell Wall of Helicobactor Pylori Binds Human IgG Deprived of Sugar Chains

YUTAKA MASUDA and TOSHIHIRO SUGIYAMA

Psychosomatic Division, Department of Biochemistry, Akita University School of Medicine, Akita 010-8543

We found a protein binding non-antibody human IgG in Helicobactor pylori cell wall, when the IgG was enzymically deglycosylated. The protein had the amino acid sequence AEDGAHVAFM. IgG of H. pylori patients also bound to the protein and the IgG lost the sugar chain structure reactivities. These findings indicate that H. pylori binds human IgG without the sugar chains on its cell wall and suggest that H. pylori infection has a relation to the human IgG deglycosylation.

Keywords —— Helicobactor pylori; human IgG; glycosylation; a protein of the cell wall

© 2001 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2001, 194, 65-69

Address for reprints: Yutaka Masuda, Psychosomatic Division, Department of Neuropsychiatry, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.