Tohoku J. Exp. Med., 2001, 193 (3)

Case Report

Acute Cholestatic Hepatitis Caused by a Probable Allergic Reaction to Paracetamol in an Adolescent

HARUHIDE SHINZAWA, HITOSHI TOGASHI, KAZUHIKO SUGAHARA, MASAMICHI ISHIBASHI, YUKI TERUI, MASANORI AOKI, HIDEKI MITSUHASHI, TAKU MATSUO, HISAYOSHI WATANABE, TAKASHI ABE, SHIGERU OHNO, KOJI SAITO, TAKAFUMI SAITO, NOBUO YAMADA, TSUNEO TAKAHASHI and RYUZO HORIUCHI

The Second Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990-9585

We reported on an adolescent who suffered from cholestatic hepatitis after taking a low dose of paracetamol. It was suspected that the condition was brought about by an allergic reaction to paracetamol. Paracetamol is one of the representative intrinsic hepatotoxic drugs. There have been only a few reports on liver damage due to an allergic reaction to paracetamol. There is a need to call attention to this particular reaction.

Keywords —— drug incuced hepatitis; drug allergy; paracetamol; adolescent

© 2001 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2001, 193, 255-258

Address for reprints: Haruhide Shinzawa, Internal Medicine, Public Okitama General Hospital, PN 992-0601, 2000 Nishi-Ohtsuka, Kawanishi Town, Yamagata 992-0601, Japan.

e-mail: shinzawa@okitama-hp.or.jp