Tohoku J. Exp. Med., 2001, 193 (3)

Case Report

A Patient with Exacerbation of Idiopathic Pulmonary Fibrosis Which was Resolved Probably due to the Coexisting Hyperbilirubinemia ?

TAKASHI OHRUI, MAKOTO HIGUCHI, AKIO KANDA, TOSHIFUMI MATSUI, EMI SATO and HIDETADA SASAKI

Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai 980-8574

This report presents the case of a patient with corticosteroid and cyclophosphamide resistant exacerbation of idiopathic pulmonary fibrosis (IPF), which was definitely resolved in accordance with increased levels of serum conjugated bilirubin due to biliary tract obstruction. Histological examination of the lung showed an accumulation of bile pigments in the alveolar mural tissues, especially in the cytoplasm of the alveolar macrophages, which play crucial roles in the development of IPF. This case suggests that bile pigments have some important roles in tissue protection against inflammatory damage in IPF, and may illustrate an important key for treatment of this fatal disorder.

Keywords —— alveolitis: reactive oxygen species: conjugated bilirubin: antioxidant activity

© 2001 Tohoku University Medical Press

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Tohoku J. Exp. Med., 2001, 193, 245-249

Address for reprints: Hidetada Sasaki, M.D., Professor and Chairman, Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai 980-8574, Japan.

e-mail: dept@geriat.med.tohoku.ac.jp