Prevention and treatment of Alzheimer's disease by conjugated linoleic acid

Saori Hata¹⁾, Toshiharu Suzuki²⁾

¹⁾Bioproduction Research Center, Advanced industrial Science and Technology (AIST)
²⁾Faculty of Pharmaceutical Sciences, Hokkaido University

Conjugated linoleic acid (CLA) is an isomer of linoleic acid (LA), an essential fatty acid.　CLA is produced naturally by symbiotic bacteria in the rumen of ruminants and is therefore found in foods such as beef and dairy products.　CLA produced by the chemical isomerization of LA is a mixture of c9,t11 CLA and t10,c12CLA.　Studies on the effects of CLA on various diseases are progressively revealing that c9,t11 CLA and t10,c12 CLA have different effects.　This review provides an overview of the previously reported functions of CLAs, with a focus on their usefulness in Alzheimer's disease.

Address correspondence to Dr. Saori Hata, Bioproduction Research Center, Advanced industrial Science and Technology (AIST)(2-17-2-1 Tsukisamu-Higashi, Toyohira-ku, Sapporo 062-8517, Japan)