Fluorin-19 MR imaging for detecting abnormal amyloid β and tau aggregates in the brain

Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama

Molecular Neuroscience Research Center, Shiga University of Medical Science

Molecular imaging targeting protein aggregates in neurodegenerative diseases have attracted much attention.　This is due to its potential to contribute to monitoring disease progression, prediction and early diagnosis in high-risk individuals.　Fluorine-19 magnetic resonance imaging （¹⁹F MRI）　using ultra-high field magnetic resonance scanner is a promising technique for such purpose, since it is a highly sensitive, easily available, low-background, cost-effective way using a suitable high-quality probe.　In this article, we describe ¹⁹F MRI probes we have recently developed, including Shiga-Y5 and Shiga-X22 for detecting amyloid pathology, Shiga-X35 for tau pathology, and Shiga-Y51 for amyloid β oligomers.

Address correspondence to Dr. Daijiro Yanagisawa, Molecular Neuroscience Research Center, Shiga University of Medical Science (Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan)