NODDI, structural network, and brain age by MRI

Hiroshi Matsuda¹⁾, Daichi Sone²⁾, Yoko Shigemoto³⁾, Noriko Sato³⁾

¹⁾Department of Biofunctional Imaging, Fukushima Medical University
²⁾Department of Psychiatry, Jikei University School of Medicine
³⁾Department of Radiology, National Center of Neurology and Psychiatry

Advances in image analysis technology have enabled MRI to provide new information that can be used for early diagnosis and prevention of dementia on an individual basis.　In this paper, we introduce NODDI processing of diffusion kurtosis images and brain age estimation and structural network analysis for structural images using standard 3D T1-weighted images of the whole brain.　In the prevention of dementia, the small-worldness obtained from structural network analysis indicating the efficiency of information transfer in the brain, was found to be significantly affected by hearing ability, glucose intolerance, renal function, and brain natriuretic peptide level.

Address correspondence to Dr. Hiroshi Matsuda, Metropolitan office of Southern Tohoku Research Institute for Neuroscience (Shin-Otemchi Building 6F, 2-2-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan)