Vascular risk factors for the development of Alzheimer’s disease:the Hisayama Study

Aiko IshikiTomoyuki Ohara¹⁾²⁾, Toshiharu Ninomiya²⁾

¹⁾Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
²⁾Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University

A population-based prospective cohort study of dementia has been conducted in Hisayama town since 1985.　The prevalence of Alzheimer’s disease increased significantly from 1985 to 2012.　In a prospective study of dementia, increased blood pressure variability, diabetes mellitus, albuminuria, and persistent smoking from midlife to late life are significant risk factors for the development of Alzheimer’s disease.　Our findings indicate that improvement and optimal management of these vascular risk factors are important to reduce the risk of Alzheimer’s disease.

Address correspondence to Dr. Tomoyuki Ohara, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University （3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan）