Disruption of sleep architecture and dementia

Risa Yamazaki¹⁾, Yu Hayashi²⁾

¹⁾The French National Centre for Scientific Research/Lyon Neuroscience Research Center
²⁾International Institute for Integrative Sleep Medicine

Nowadays many people suffer from sleep-related problems, which not only negatively affect our daily life, but also may contribute to the progression of various diseases.　In particular, there is growing evidence that support relations between sleep and dementia, which is one of the biggest health issues in the world.　Abnormal sleep including REM behavior disorder often precedes dementia, and poor sleep in turn might promote the accumulation of brain waste such as amyloid-β.　Sleep also plays important roles in learning and memory via diverse mechanisms.　Here, we review recent findings on sleep functions in dementia and learning and memory.

Address correspondence to Dr. Yu Hayashi, International Institute for Integrative Sleep Medicine（1-1-1 Tennodai, Tsukuba 305-8575, Japan）