Neuropathology of dementia with Lewy bodies

Mari Yoshida

Institute for Medical Science of Aging, Aichi Medical University

To investigate the clinicopathological features of Lewy body disease (LBD), a series of 64 subjects with autopsy-proven LBD was studied according to the third report of the DLB consortium diagnostic criteria. According to the 1-year rule, 19 cases (30%) were classified into 1-year rule group and 45 cases (70%) into non-1-year rule group. The pathological diagnosis of diffuse neocortical form was 39%, limbic form 47%, and brainstem form 14%, respectively. The likelihood of occurrence of the DLB was high in 67%, intermediate in 17%, and low in 16%. The pathological involvement of peripheral autonomic system (PAS) showed different patterns in 1-year rule group. Therefore, the investigation of PAS is one of the important factors to assess the LBD pathophysiology.

Address correspondence to Dr. Mari Yoshida, Institute for Medical Science of Aging, Aichi Medical University (1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan)