Gene and biomarker of Alzheimer’ disease

Gene and biomarker of Alzheimer' disease

Ryozo Kuwano¹⁾, Tamao Tsukie²⁾

¹⁾Department of Molecular Genetics, Brain Research Institute, Niigata University
²⁾Research Association for Biotechnology

Alzheimer's disease (AD) is the most common form of dementia in the elder. There are rare cases of familiar AD characterized by the early onset with autosomal dominant inheritance. The majority of AD is the late onset sporadic feature. Genetic factors are thought to play an important role in the onset and progression of AD. Recently the causative genes have been found also in the sporadic early onset AD. In addition to APP duplication, new duplicated regions including several genes were reported. The concentration of CSF Aβ42, total tau and phosphorylated tau, the neuroimaging profiles and APOE genotyping as the biomarkers have been evaluated to predict the preclinical stage of AD progression.

Address correspondence to Dr. Ryozo Kuwano, Department of Molecular Genetics, Brain Research Institute, Niigata University