The clinical features and treatment of BPSD in patients with DLB

Mamoru Hashimoto¹⁾, Keiichiro Kaneda¹⁾, Manabu Ikeda^1,2)

¹⁾Department of Neuropsychiatry, Kumamoto University Hospital
²⁾Department of Psychiatry and Neuropathobiology, Faculty of Lifesciences, Kumamoto University

Recent literatures suggest that behavioral and psychological symptoms of dementia (BPSD) are frequently associated with DLB. Among a number of BPSD, delusions are clinically important symptoms in DLB for high prevalence and their refractoriness. The principal component analysis for eight types of delusions in DLB revealed that misidentificational delusion and contents specific delusion such as delusional theft or delusional jealousy might related reciprocally. Aripiprazole, an atypical antipsychotic with partial agonism at D2 receptors, held promise as a antipsychotic in DLB when it was available, but the present case series study reported negative findings. Clinicians must ensure a balance between tolerability and clinical benefit on the treatment of DLB.

Address correspondence to Dr. Mamoru Hashimoto, Department of Neuropsychiatry, Kumamoto University Hospital (1-1-1 Honjo, Kumamoto 860-8556, Japan)