A oligomers

Etsuro Matsubara

Deaprtment of Alzheimer's Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology

Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers, play a causative role in Alzheimer's disease. The precise understanding of Aβ oligomers is prerequisite for therapeutic intervention for Alzheimer's disease. From this point of view, I review the recent finding on Aβ oligomers, with special emphasis on neurotoxic molecules which could trigger a complex downstream cascade leading to the symptom of Alzheimer's disease.

Address correspondence to Dr. Etsuro Matsubara, Deaprtment of Alzheimer's Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology (36-3, Gengo, Moriokamachi, Obu-shi, Aichi 474-8522, Japan)