Dementia Japan 19：256-265, 2005

Hyperlipidemia, statin and Alzheimer disease

Tsuneo Yamazaki

Gunma University, Graduate School of Medicine, Department of Neurology

　　In recent years, a great deal of attention has been paid for the relationship between Alzheimer disease and hyperlipidemia, especially hypercholestereolmia.　Results from both in vitro and in vivo basic researches suggest that the cellular cholesterol contents might affect amyloid β production, and lowering cellular cholesterol might reduce the risk of the disease.　However, epidemiological studies raise a controversy whether the statin use prevents the disease progression.　Apparently, more clinical studies are needed for elucidating the statin use for preventing Alzheimer disease.

Address correspondence to Dr. Tsuneo Yamazaki, Gunma University, Graduate School of Medicine, Department of Neurology (3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan)