E-3. Modifications of immunological and neuroendocrine responses induced by stimulated microgravity using head-down bed rest（HDBR）and countermeasure with artificial gravity and exercise in humans

一般演題

Dominika Kanikowska‚ Maki Sato‚ Satoshi Iwase‚ Yuuki Shimizu‚ Yoko Inukai‚ Naoki Nishimura‚ Junichi Sugenoya

Department of Physiology‚ Aichi Medical University School of Medicine‚ Nagakte‚ Japan

　Head-down bed rest of －6°（HDBR）is used as a model for studying the physiological changes during microgravity in spaceflight. The aim of the present study was to investigate whether exposure to the “stress” environment are responsible for alterations in synthesis of some acute phase proteins and cytokines. In this study 12 male volunteers were subjected for 20 days to a HDBR of －6°. Plasma norepinephrine (NE)‚ epinephrine (Epi)‚ dopamine(DA)‚leukocyte(WBC)‚interleukin6(IL-6)‚total serum protein (TP)‚ C-reactive protein (CRP) and α-1antichimotrypsin (ACT) were determined before and after HDBR of -6°. Epi and NE concentrations increased significantly and concentration of CRP decreased (ANOVA p<0.05). The results of this study indicate that several neuroendocrine and immunological parameters are modulated by a prolonged antigravity posture during HDBR of －6°.