福島医学雑誌 61 巻 2 号 2011
〔症例報告〕
CPT-11/CDDP併用化学療法が著効した食道内分泌細胞癌の1例
浅間 宏之1)，若槻 尊1)，浅野 智之2)，黒田 聖仁2)，寺島久美子2)，宮田 昌之2)，大平 弘正3)
1)福島赤十字病院消化器科，2)同 内科，3)福島県立医科大学医学部消化器·リウマチ膠原病内科学講座
（受付2011年2月10日 受理2011年5月19日）
A Case of Endocrine Cell Carcinoma of the Esophagus with Remarkable Response to Combination Chemotherapy with CPT-11 and CDDP
HIROYUKI ASAMA1）, TAKERU WAKATSUKI1）, TOMOYUKI ASANO2）, MASAHITO KURODA2）, KUMIKO TERASHIMA2）, MASAYUKI MIYATA2） and HIROMASA OHIRA3）
1）Fukushima Red Cross Hospital, Department of Gastroenterology, 2）Fukushima Red Cross Hospital, Department of Internal Medicine, 3）Fukushima Medical University School of Medicine, Department of Gastroenterology and Rheumatology
要旨: 症例は59歳男性。嚥下時のつかえ感を主訴に来院し，上部消化管内視鏡検査で胸部食道に約12cmに渡り2型腫瘍が認められ，生検にて内分泌細胞癌の診断であった。CTでは縦隔および腹腔リンパ節腫大，多発肝転移を認め，また肺野には異常陰影を認めず，stage IVbの食道内分泌細胞癌と診断された。肺小細胞癌に準じ塩酸イリノテカン（CPT-11）/シスプラチン（CDDP）併用化学療法を開始した。2クール施行後のCTでは，著明な腫瘍縮小効果を確認した。治療開始からの無増悪生存期間は8カ月，生存期間は16カ月であった。CPT-11/CDDP併用化学療法が著効を呈した，食道内分泌細胞癌の1例を経験した。
索引用語: 食道内分泌細胞癌，化学療法，CPT-11/CDDP
Abstract: Endocrine cell carcinoma of the esophagus is rare disease. There is no standard therapy and the prognosis is extremely poor. Here we reported a case of endocrine cell carcinoma of the esophagus with multiple metastasis was well responded to combination chemotherapy with CPT-11 and CDDP. The patient was 59-year-old man who was suffering from dysphagia and esophagogastroduodenoscopy revealed type 2 tumor in the esophagus. The biopsy speciemen revealed endocrine cell carcinoma. Multiple liver and lymph node metastesis in mediastinum and abdominal cavity were shown by CT scan. He was diagnosed as primary endocrine cell carcinoma of the esophagus. Then he was administrated CDDP 60mg/m2 （day 1） and CPT-11 60mg/m2 （day 1, 8, 15） were infused once a week for 3 weeks followed by 1 week interval. Primary tumor and metastasis were markedly reduced, however he was finally died due to brain metastasis. Progression free survival and overall survival were 8 months and 16 months, respectively.
Key words: Endocrine cell carcinoma, Esophageal cancer, chemotherapy, CPT-11-cisplatin
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