Fukushima J. Med. Sci.,Vol. 55, No. 2, 2009

[Original Article]

REVERSAL OF VECURONIUM WITH NEOSTIGMINE :
A COMPARISON BETWEEN MALE AND FEMALE PATIENTS

YUHJI SAITOH¹⁾, KENICHI AOKI²⁾, MICHIYA OKAZAKI²⁾,
TAKAHIRO HIRAMA²⁾, TSUYOSHI ISOSU²⁾
and MASAHIRO MURAKAWA²⁾

¹⁾Department of Anesthesiology, Tsujinaka Hospital Kashiwanoha, Chiba, Japan, ²⁾Department of Anesthesiology, Fukushima Medical University School of Medicine, Fukushima, Japan

(Received January 17, 2009, accepted March 17, 2009)

Abstract: We investigated the differences between males and females in the reversal effect of neostigmine on neuromuscular blockade. Thirty male and 30 female patients undergoing elective general anesthesia were studied. Vecuronium was given in all patients anesthetized with nitrous oxide, oxygen, and sevoflurane. After the surgical procedure, when T1 (1st response in train-of-four (TOF))/control returned to 0.25, neostigmine 40 μg/kg in combination with atropine 20 μg/kg was given to antagonize residual neuromuscular blockade. Three, six, nine, 12, and 15 minutes after neostigmine reversal, T1/control or TOF ratio (T4/T1) did not significantly differ between the sexes. Also, 15 minutes after neostigmine administration, the number of patients in whom recovery from neuromuscular blockade was sufficient to guarantee good respiratory function, i.e., TOF ratio>0.74, did not significantly differ between the sexes. In contrast, 15 minutes after neostigmine, the number of patients in whom recovery from neuromuscular blockade was adequate to ensure satisfactory recovery from neuromuscular blockade including the return of the faculty of sight, i.e., TOF ratio>0.9, was significantly less in the males than in females (6 vs 14, P=0.028). In conclusion, 15 min after neostigmine, TOF ratio less often returns to a value of more than 0.9 in males than in females.

Key words: gender, vecuronium, neostigmine

齋藤祐司，青木健一，岡崎美智弥，平間孝広，五十洲剛，村川雅洋

Corresponding author: Yuhji Saitoh
E-mail: ysr311@auone.jp
http://fmu.ac.jp/home/lib/F-igaku/
http://www.sasappa.co.jp/online/