Fukushima J. Med. Sci.,
Vol. 53, No. 1, 2007

[Case Report]

A CASE OF ESOPHAGEAL SMALL CELL CARCINOMA ASSOCIATED
WITH HYPERCALCEMIA CAUSING SEVERE
ACUTE PANCREATITIS

KAORI KANNO¹⁾, TAKUTO HIKICHI²⁾, KEIETSU SAITO¹⁾,
KENYA WATANABE¹⁾, TADAYUKI TAKAGI¹⁾, GORO SHIBUKAWA¹⁾,
TAKERU WAKATSUKI¹⁾, HIDEMICHI IMAMURA¹⁾, YUTA TAKAHASHI¹⁾,
AI SATO¹⁾, MASAKI SATO¹⁾, ATSUSHI IRISAWA¹⁾, KATSUTOSHI OBARA²⁾
and HIROMASA OHIRA¹⁾

¹⁾Department of Internal Medicine II, Fukushima Medical University School of Medicine,
Fukushima, 960-1295, Japan
²⁾Department of Endoscopy, Fukushima Medical University Hospital,
Fukushima, 960-1295, Japan

(Received July 30, 2006, accepted April 12, 2007)

Abstract: A 60-year-old woman was diagnosed with esophageal small cell carcinoma in October 2004 and received chemotherapy. However, the tumor grew gradually and multiple bone metastases occurred. Anorexia, nausea, emesis, numbness in both hands, and disturbed consciousness developed at the end of January 2006, and the patient was admitted to Fukushima Medical University Hospital. Abdominal pain, marked hypercalcemia and hyperamylasemia were noted and the patient was diagnosed with severe acute pancreatitis. Because the level of blood parathyroid hormone-related protein was elevated, we considered that esophageal small cell carcinoma caused human hypercalcemia of malignancy and that metastatic bone tumors caused local osteolytic hypercalcemia, eventually leading to severe acute pancreatitis. This is an extremely rare case of esophageal small cell carcinoma associated with hypercalcemia causing severe acute pancreatitis.

Key words: esophageal carcinoma, small cell carcinoma, severe acute pancreatitis, hypercalcemia, EUS-FNA

菅野　香，引地拓人，斎藤桂悦，渡辺研也，高木忠之，渋川悟朗，若槻　尊，今村秀道，橋裕太，佐藤　愛，佐藤匡記，入澤篤志，小原勝敏，大平弘正

Correspondence to: Kaori Kanno, Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima City 960-1295, Japan.
E-mail: kaori@fmu.ac.jp