Fukushima J. Med. Sci.,
Vol. 53, No. 1, 2007
[Original Article]
ORNITHINE DECARBOXYLASE ACTIVITY AS A PROGNOSTIC
MARKER FOR COLORECTAL CANCER
YUTAKA HOSHINO1), SHINYA TERASHIMA2), YASUSHI TERANISHI3),
MASANORI TERASHIMA1), MICHIHIKO KOGURE1), TAKUROH SAITOH1),
FUMIHIKO OSUKA1), SEIGO KASHIMURA1), ZENICHIROH SAZE1)
and MITSUKAZU GOTOH1)
1)Department of Surgery I, Fukushima Medical University School of Medicine
2)Department of Surgery, Fujita General Hospital
3)Department of Surgery, Southern Tohoku General Hospital
(Received January 22, 2007, accepted March 5, 2007)
Abstract: Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, which are essential for cell proliferation. ODC activity was measured in 47 colorectal cancer patients, 5 patients with adenoma of colorectum and 4 healthy volunteers. Mean ODC activities of cancer tissue, non-cancerous mucosa from cancer-bearing colorectum, adenoma tissue, and normal mucosa from healthy volunteers were 435±392, 154±173, 295±202, 103±60 pmol CO2/h/mg protein, respectively. ODC activity of cancer tissue or adenoma tissue was significantly higher than that of the others. Among colorectal cancer patients, ODC activity in cancer tissue was correlated with T factors, lymph node metastasis and stages. Patients with tumors that had high ODC activity (≥350 pmol CO2/h/mg protein) showed a poor 10-year survival rate. These results suggest that ODC activity may be a useful marker for patients' prognosis after surgery.
Key words: ornithine decarboxylase activity, colorectal cancer, biological marker
星野 豊，寺島信也，寺西 寧，寺島雅典，木暮道彦，斎藤拓朗，大須賀文彦，樫村省吾，佐瀬善一郎，後藤満一
Correspondence to: Hikarigaoka 1, Fukushima City, Fukushima Prefecture.
E-mail: yhoshino@fmu.ac.jp