Fukushima J. Med. Sci.,
Vol. 52, No. 2, 2006

[Original Article]

EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW
IN RATS WITH LIVER CIRRHOSIS DETERMINED
BY ANALYZING GASTRIC BLOOD FLOW,
PORTAL VEIN PRESSURE AND BLOOD GAS

FUJIO TAKIGUCHI, ATSUSHI IRISAWA, AYAKO SAITO,
HIROAKI SAKAMOTO, KATSUTOSHI OBARA, REIJI KASUKAWA
and HIROMASA OHIRA

Department of Internal Medicine II, Fukushima Medical University, School of Medicine,
Fukushima, 960-1295, Japan

(Received July 13, 2006, accepted September 22, 2006)

Abstract: We investigated the effects of isosorbide dinitrate (IDN) on gastric blood flow (GBF), portal venous pressure (PVP) and blood gas of rats with liver cirrhosis (LC) accompanied by portal hypertension. Thirty male Wistar rats (LC in 17 and normal in 13) were used. Before and after IDN administration, GBF, PVP and blood gas in the femoral artery and portal vein were measured. Portal blood oxygen concentration was estimated by calculating the ratio of PO₂ in portal blood and that in arterial blood (PpvO₂/PaO₂) of each rat. The GBF in the LC rats was significantly lower than that in the normal rats. In the LC group, IDN administration significantly increased the GBF. The PpvO₂/PaO₂ value in the group with LC was significantly lower after IDN administration than that before IDN administration. In the investigation whether changes in PVP or Ppv/PaO₂ contributed more to the change in GBF after IDN administration, a significant correlation was found between rates of change in GBF and PpvO₂/PaO₂ were significantly correlated (r=−0.733, p<0.05). The effect of IDN on changes in the stomach accompanying portal hypertension is mainly attributable to a decrease in preload, which suppresses inflow to the stomach, as reflected by a decrease in PpvO₂/PaO₂, rather than to a decrease in afterload on GBF, as reflected by a decrease in PVP.

Key words: Portal hypertension, Portal hypertensive gastropathy, Isosorbide dinitrate

滝口藤夫，入澤篤志，齋藤文子，坂本弘明，小原勝敏，粕川禮司，大平弘正

Correspondence to: Atsushi Irisawa, Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima City 960-1295, Japan.
E-mail: irisawa@fmu.ac.jp