Fukushima J. Med. Sci.,
Vol. 51, No. 1, 2005

［Original Article］

ANTI-RIBOSOMAL P ANTIBODIES ARE ASSOCIATED WITH NEPHRITIS,
VASCULAR THROMBOSIS AND LYMPHOCYTOPENIA IN PATIENTS
WITH SYSTEMIC LUPUS ERYTHEMATOSUS

ISAO TAKEDA¹⁾, HARUYO IWADATE¹⁾, KOTA SUGISAKI¹⁾,
ATSUSHI TAKAHASHI¹⁾, SYOJI NOGAE²⁾,
TAKASHI KANNO¹⁾ and REIJI KASUKAWA¹⁾

¹⁾Divisions of Rheumatology and ²⁾Nephrology, Ohta Nishinouchi Hospital,
Koriyama, 963-8558, Japan

(Received October 18, 2004, accepted November 16, 2004)

Abstract: In the present study, anti-ribosomal P antibody in sera of patients with systemic lupus erythematosus was assayed using an enzyme-linked immunosorbent assay, and its association with clinical symptoms of the patients was analyzed.　The presence of anti-ribosomal P antibody was associated with increased frequency of lupus nephritis in the presence of anti-DNA antibody, and was associated with increased frequency of vascular thrombosis in the presence of anti-b2 glycoprotein I antibody and/or lupus anticoagulant.　The level of anti-ribosomal P antibody correlated inversely with the peripheral lymphocyte counts.

Key words: anti-DNA antibody, anti-ribosomal P antibody, lupus nephritis, lymphocytopenia, vascular thrombosis

武田　功，岩舘治代，杉崎康太，高橋敦史，野替正二，菅野　孝，粕川禮司

Correspondence to: Reiji Kasukawa, Division of Rheumatology, Ohta Nishinouchi Hospital, 2-5-20 Nishinouchi, Koriyama City 963-8558, Japan.
E-mail: rkasukaw@ohta-hsp.or.jp