Fukushima J. Med. Sci.
Vol. 48, No. 2, 2002

［Case Reports］

PREVENTION OF PROGRESSION OF INTERSTITIAL LUNG LESIONS BY
EARLY COMBINATION THERAPY WITH CORTICOSTEROIDS AND
CYCLOSPORINE/CYCLOPHOSPHAMIDE IN TWO PATIENTS WITH
AMYOPATHIC DERMATOMYOSITIS

KOTA SUGISAKI¹⁾, ISAO TAKEDA¹⁾, HARUYO IWADATE¹⁾,
TAKASHI KANNO¹⁾, TOMOE NISHIMAKI²⁾
and REIJI KASUKAWA¹⁾

¹⁾Division of Rheumatology, Ohta Nishinouchi Hospital, Koriyama
²⁾Nishimaki Clinic, Sukagawa

(Received September 20, 2002, accepted November 20, 2002)

Abstract: Two patients with amyopathic dermatomyositis complicated by interstitial lung lesions were effectively treated with a combination of corticosteroids and cyclosporine and/or cyclophosphamide. A 48-year-old female patient was treated with pulse methylprednisolone and cyclosporine 2 months after onset of dermal symptoms. A 45-year-old male patient was treated with oral prednisolone and pulse cyclophosphamide 2 1/2 months after onset of dermal symptoms. Early evaluation of interstitial lung lesions and early extensive therapy may improve prognosis of interstitial lung lesions in patients with amyopathic dermatomyositis.

Key words: interstitial lung lesion, immunosuppressant, combination therapy

杉崎康太，武田功，岩館治代，菅野孝，西間木友衛，粕川禮司

Reprint requests to: Kota Sugisaki, Division of Rheumatology, Fukushima Rosai Hospital, Iwaki City, 973-8403, Japan.