ANTIKERATIN ANTIBODIES IN SERA OF PATIENTS WITH CONNECTIVE TISSUE DISEASE AND LIVER DISEASE

［Regular Papers］

ANTIKERATIN ANTIBODIES IN SERA OF PATIENTS WITH
CONNECTIVE TISSUE DISEASE AND LIVER DISEASE

ISAO TAKEDA¹⁾, HARUYO IWADATE¹⁾, KOTA SUGISAKI¹⁾,
TAKASHI KANNO¹⁾, JOTARO SHINZAWA²⁾ and REIJI KASUKAWA¹⁾

¹⁾Divisions of Rheumatology and ²⁾Digestive Organ Disease, Ohta Nishinouchi Hospital, Koriyama

(Received April 30, 2002, accepted May 27, 2002)

Abstract: Sera from 93 patients with connective tissue disease, 36 rheumatoid arthritis, 41 systemic lupus erythematosus, 12 polymyositis/dermatomyositis and 4 systemic sclerosis and sera from 12 patients with liver disease, along with sera of 10 healthy subjects, were tested for antikeratin antibodies using enzyme-linked immunosorbent assay in which the wells were coated with human epidermal keratin.
Values above the mean＋SD of the 10 healthy subjects were found in 8.3% of rheumatoid arthritis, 29.3% of systemic lupus erythematosus, 33.3% of polymyositis/dermatomyositis, 50% of systemic sclerosis, 16.7% of liver disease patients, and 20% of healthy subjects. The results indicated a character of naturally occurring antibody of antikeratin antibodies in human sera.

Key words: keratin antibody, natural antibody, ELISA, connective tissue disease, liver disease

武田功，岩舘治代，杉崎康太，菅野孝，新澤穣太郎，粕川禮司

Reprint requests to: Reiji Kasukawa, Institute of Rheumatic Diseases, Ohta General Hospital Foundation, Koriyama City 963-8004, Japan.